Parasite. 2008 Sep;15(3):359-65.

Nosocomial Pneumocystis jirovecii infections.

Nevez G, Chabé M, Rabodonirina M, Virmaux M, Dei-Cas E, Hauser PM, Totet A.

Source

Laboratoire de Parasitologie et Mycologie, Hôpital Augustin Morvan, CHU, Brest, France. gilles.nevez@chu-brest.fr

Abstract

Airborne transmission of Pneumocystis sp. from host to host has been demonstrated in rodent models and several observations suggest that interindividual transmission occurs in humans. Moreover, it is accepted that the Pneumocystis organisms infecting each mammalian species are host specific and that the hypothesis of an animal reservoir for Pneumocystis jirovecii (P. jirovecii), the human-specific Pneumocystis species, can be excluded. An exosaprophytic form of the fungus cannot be strictly ruled out. However, these data point toward the potential for the specific host to serve as its own reservoir and for Pneumocystis infection in humans as an anthroponosis with humans as a reservoir for P. jirovecii. This review highlights the main data on host-to-host transmission of Pneumocystis in rodent models and in humans by the airborne route and provides a rationale for considering the occurrence of nosocomial infections and measures for their prevention

PMID:: 18814707; [PubMed - indexed for MEDLINE]

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Cited by 3 PubMed Central articles

Possible nosocomial transmission of Pneumocystis jirovecii. [Emerg Infect Dis. 2012]
Possible nosocomial transmission of Pneumocystis jirovecii.
Damiani C, Choukri F, Le Gal S, Menotti J, Sarfati C, Nevez G, Derouin F, Totet A. Emerg Infect Dis. 2012 May; 18(5):877-8.
High prevalence of dihydropteroate synthase mutations in Pneumocystis jirovecii isolated from patients with Pneumocystis pneumonia in South Africa. [J Clin Microbiol. 2010]
High prevalence of dihydropteroate synthase mutations in Pneumocystis jirovecii isolated from patients with Pneumocystis pneumonia in South Africa.
Dini L, du Plessis M, Frean J, Fernandez V. J Clin Microbiol. 2010 Jun; 48(6):2016-21. Epub 2010 Mar 29.
Hypothetical Pneumocystis jirovecii transmission from immunocompetent carriers to infant. [Emerg Infect Dis. 2009]
Hypothetical Pneumocystis jirovecii transmission from immunocompetent carriers to infant.
Hauser P, Rabodonirina M, Nevez G. Emerg Infect Dis. 2009 Mar; 15(3):506-7; author reply 507.

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