-
The B-cell antigen receptor of the five immunoglobulin classes.
MRC Laboratory of Molecular Biology, Cambridge, UK.
Several proteins associate with surface IgM to form the antigen receptor. We show that just two, the alpha and beta associated chains, are sufficient to reconstitute an IgM surface receptor in fibroblasts. Contrary to expectation, a common alpha chain associates with all five immunoglobulin classes. We propose that B-cell antigen receptors consist of a common alpha/beta heterodimer associated with each immunoglobulin class. But the classes differ both in the glycosylation of their associated alpha chain and in their dependence on alpha/beta for surface transport.
PMID: 1881434 [PubMed - indexed for MEDLINE]
-
Cited by 37 PubMed Central articles
-
B cell receptor accessory molecules in the channel catfish, Ictalurus punctatus.
Sahoo M, Edholm ES, Stafford JL, Bengtén E, Miller NW, Wilson M.
Dev Comp Immunol. 2008; 32(11):1385-97. Epub 2008 Jun 10.
[Dev Comp Immunol. 2008]
-
IgG1 B cell receptor signaling is inhibited by CD22 and promotes the development of B cells whose survival is less dependent on Ig alpha/beta.
Waisman A, Kraus M, Seagal J, Ghosh S, Melamed D, Song J, Sasaki Y, Classen S, Lutz C, Brombacher F, et al.
J Exp Med. 2007 Apr 16; 204(4):747-58. Epub 2007 Apr 9.
[J Exp Med. 2007]
-
ReviewModels of signal transduction through the B-cell antigen receptor.
Geisberger R, Crameri R, Achatz G.
Immunology. 2003 Dec; 110(4):401-10.
[Immunology. 2003]
- » See all...