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Cornea. 2008 Sep;27 Suppl 1:S9-11. doi: 10.1097/ICO.0b013e31817f4075.

Epithelial-immune cell interaction in dry eye.

Author information

  • 1Ocular Surface Center, Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, Houston, TX 77030, USA. stevenp@bcm.tmc.edu

Abstract

Dry eye is a potent stimulus of both innate and adaptive immune systems. At the nexus of the dry eye inflammatory/immune response is the dynamic interplay between the ocular surface epithelia and the bone marrow-derived immune cells. On the one hand, ocular surface epithelial cells play a key initiating role in this inflammatory reaction. On the other hand, they are targets of cytokines produced by activated T cells that are recruited to the ocular surface in response to dry eye. This interaction between epithelial and immune cells in dry eye will be thoroughly reviewed.

PMID:
18813079
[PubMed - indexed for MEDLINE]
PMCID:
PMC4082978
Free PMC Article
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