OBJECTIVE:

For certain brainstem lesions, a diagnostic biopsy is required for treatment planning. We reviewed the indications, safety, and diagnostic effectiveness of a transcerebellar stereotactic biopsy using local anesthesia and sedation.

METHODS:

We retrospectively reviewed hospital records for all adult patients with symptomatic lesions of the pons and/or cerebellar peduncle who underwent an awake transcerebellar stereotactic biopsy at our institution over a 7-year period. Our technique features several modifications from the standard method and was performed under local anesthesia with patients in the semi-sitting position.

RESULTS:

Our rate of diagnostic success (92%) was comparable to those in other published reports. However, only 5 (42%) of 12 biopsy-derived diagnoses were consistent with those predicted from preoperative magnetic resonance imaging. There were no deaths, and the only neurological complication was a cranial nerve palsy. Diagnoses in the 13 cases included infiltrative glioma (), metastases (), lymphoma (), encephalitis (), and reactive astrogliosis ().

CONCLUSION:

Tissue diagnosis of lesions in the brainstem and cerebellar peduncles continues to be a significant challenge, with the potential for major morbidity. With appropriate patient selection, however, awake transcerebellar biopsy is a safe and effective procedure that can change clinical management and provide important prognostic information.