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Neurosci Res. 2008 Dec;62(4):236-9. doi: 10.1016/j.neures.2008.08.010. Epub 2008 Sep 4.

Natural antisense transcripts are co-expressed with sense mRNAs in synaptoneurosomes of adult mouse forebrain.

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  • 1Department of Psychiatry and Psychiatric Institute, University of Illinois-Chicago, 1601 W. Taylor Street MC912, Chicago, IL 60612, USA. neils@uic.edu


Natural antisense transcripts and overlapping sense transcripts are expressed in a variety of tissues, including adult mouse brain. Here we show that a subset of mRNA-like sense-antisense transcript pairs are co-expressed within synaptoneurosomes of adult mouse forebrain, a subcellular fraction that is enriched in pinched-off dendritic spines of pyramidal neurons. Several of these pairs involve mRNAs that have been implicated in synaptic functions and in Alzheimer disease pathways. This study provides evidence that a new class of noncoding RNAs (natural antisense transcripts) are expressed near synapses, and encourages further studies of their roles in neuronal function.

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