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Antimicrob Agents Chemother. 2009 Jan;53(1):256-60. doi: 10.1128/AAC.00470-08. Epub 2008 Sep 22.

Antifungal activities of human beta-defensins HBD-1 to HBD-3 and their C-terminal analogs Phd1 to Phd3.

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  • 1Centre for Cellular and Molecular Biology, Council of Scientific and Industrial Research, Hyderabad, India.

Abstract

The activities of defensins HBD-1, HBD-2, and HBD-3 and their C-terminal analogs Phd1, Phd2, and Phd3 against Candida albicans were investigated. Phd1 to Phd3 showed lower-level activities than HBD-1 to HBD-3, although metabolic inhibitors did not render Phd1 to Phd3 inactive. Their activities were also less salt sensitive than those of HBD-1 to HBD-3. Confocal microscope images indicated that the initial site of action was the fungal membrane.

PMID:
18809937
[PubMed - indexed for MEDLINE]
PMCID:
PMC2612179
Free PMC Article
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