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J Exp Med. 2008 Sep 29;205(10):2187-90. doi: 10.1084/jem.20081736. Epub 2008 Sep 22.

Chemerin reveals its chimeric nature.

Author information

  • 1Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA. yoshimut@mail.nih.gov

Abstract

Chemerin is a proinflammatory plasma protein that binds to the GPCR ChemR23/CMKLR1 on macrophages and plasmacytoid dendritic cells, and promotes chemotaxis. An orphan GPCR, CCRL2, has now been identified as an additional receptor for chemerin, providing a unique mechanism by which chemerin enhances inflammation. Furthermore, because recent data shows that chemerin-derived peptides possess antiinflammatory properties, chemerin may be involved in both the initiation and resolution of inflammation.

PMID:
18809717
[PubMed - indexed for MEDLINE]
PMCID:
PMC2556799
Free PMC Article
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