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1: Semin Immunol. 2009 Feb;21(1):14-21. Epub 2008 Sep 21.Click here to read Links

From the diet to the nucleus: vitamin A and TGF-beta join efforts at the mucosal interface of the intestine.

Mucida D, Park Y, Cheroutre H.

La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.

The vitamin A metabolites, including retinoic acid (RA), form ligands for retinoic acid-related nuclear receptors and together they play pleiotropic roles in various biological processes. Recently, we described that RA also functions as a key modulator of transforming growth factor-beta (TGF-beta)-driven immune deviation, capable of suppressing the differentiation of interleukin-17 secreting T helper cells (T(H)17) and conversely promoting the generation of Foxp3(+) T regulatory (Treg) cells. This review will focus on the role of RA in the reciprocal TGF-beta-driven differentiation of T(H)17 and Treg and on the importance of such regulatory mechanism to control a functional immune system, in particular at the mucosal interface of the intestine.

PMID: 18809338 [PubMed - indexed for MEDLINE]

PMCID: PMC2643336 [Available on 2010/02/01]

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