BACKGROUND: A sharp rise in the malaria mortality rate has been observed recently in western Kenya. Malaria is transmitted by mosquito vectors. Malaria control strategies can be more successful if the distribution and abundance of mosquito vectors is predicted. However, how mosquito vectors are distributed in space remain poor understood, and this question is rarely studied using spatial methods. This study aims to provide a better understanding of the distribution and abundance of mosquito vectors. To achieve this objective, spatial and non-spatial methods were employed. The data on the distribution of adult mosquitoes, and mosquito breeding habitats in a study area in western Kenya, and environmental variables were analyzed. RESULTS: The models developed using spatial methods outperformed the models developed using non-spatial methods. Houses close to locations where mosquito breeding habitats were repeatedly observed had more abundant adult female mosquitoes. Distance to high-order streams was identified as an effective predictor for the distribution of adult mosquitoes. CONCLUSION: The spatial method is more effective in modeling the distribution of adult mosquitoes than the non-spatial method. The results of this study can be used to facilitate decision-making related to mosquito surveillance and malaria prevention.