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    Infect Control Hosp Epidemiol. 2008 Oct;29(10):975-7.

    Coadministration of oral levofloxacin with agents that impair absorption: impact on antibiotic resistance.

    Cohen KA, Lautenbach E, Weiner MG, Synnestvedt M, Gasink LB.

    Divisions of Infectious Diseases, Departments of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

    Coadministration of oral divalent or trivalent cation-containing compounds with oral fluoroquinolones may impair fluoroquinolone absorption. Among 3,134 patients who received a course of oral levofloxacin, coadministration was significantly associated with subsequent identification of a levofloxacin-resistant isolate. Strategies to curb the emergence of fluoroquinolone resistance should include avoiding the coadministration of divalent or trivalent cation-containing compounds and fluoroquinolone.

    PMID: 18808343 [PubMed - indexed for MEDLINE]

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    • Levofloxacin (Levaquin®)

      Levofloxacin is used to treat certain infections such as pneumonia chronic bronchitis and sinus, urinary tract, kidney, prostate (a male reproductive gland), and skin infections. Levofloxacin is also used to prevent anth...

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      Ofloxacin is used to treat certain infectionsincluding bronchitis, pneumonia, and infections of the skin, bladder, urinary tract, reproductive organs, and prostate (a male reproductive gland). Ofloxacin is in a class of ...

    • Source: AHFS Consumer Medication Information

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