Nature. 2008 Oct 23;455(7216):1114-8. Epub 2008 Sep 17.

Conjugated action of two species-specific invasion proteins for fetoplacental listeriosis.

Disson O, Grayo S, Huillet E, Nikitas G, Langa-Vives F, Dussurget O, Ragon M, Le Monnier A, Babinet C, Cossart P, Lecuit M.

Source

Institut Pasteur, Groupe Microorganismes et Barrières de l'Hôte, Unité des Interactions Bactéries-Cellules, F-75015 Paris, France.

Abstract

The ability to cross host barriers is an essential virulence determinant of invasive microbial pathogens. Listeria monocytogenes is a model microorganism that crosses human intestinal and placental barriers, and causes severe maternofetal infections by an unknown mechanism. Several studies have helped to characterize the bacterial invasion proteins InlA and InlB. However, their respective species specificity has complicated investigations on their in vivo role. Here we describe two novel and complementary animal models for human listeriosis: the gerbil, a natural host for L. monocytogenes, and a knock-in mouse line ubiquitously expressing humanized E-cadherin. Using these two models, we uncover the essential and interdependent roles of InlA and InlB in fetoplacental listeriosis, and thereby decipher the molecular mechanism underlying the ability of a microbe to target and cross the placental barrier.

PMID:: 18806773; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Secondary Source ID, Grant Support

Publication Types

Research Support, Non-U.S. Gov't

MeSH Terms

Substances

Secondary Source ID

Grant Support

Howard Hughes Medical Institute/United States

LinkOut - more resources

Full Text Sources

Medical

Molecular Biology Databases

KOMP Repository

Miscellaneous

Mouse Genome Informatics (MGI)

Supplemental Content

Save items

Related citations in PubMed

Targeting and crossing of the human maternofetal barrier by Listeria monocytogenes: role of internalin interaction with trophoblast E-cadherin. [Proc Natl Acad Sci U S A. 2004]
Targeting and crossing of the human maternofetal barrier by Listeria monocytogenes: role of internalin interaction with trophoblast E-cadherin.
Lecuit M, Nelson DM, Smith SD, Khun H, Huerre M, Vacher-Lavenu MC, Gordon JI, Cossart P. Proc Natl Acad Sci U S A. 2004 Apr 20; 101(16):6152-7. Epub 2004 Apr 8.
Species specificity of the Listeria monocytogenes InlB protein. [Cell Microbiol. 2006]
Species specificity of the Listeria monocytogenes InlB protein.
Khelef N, Lecuit M, Bierne H, Cossart P. Cell Microbiol. 2006 Mar; 8(3):457-70.
Review Understanding how Listeria monocytogenes targets and crosses host barriers. [Clin Microbiol Infect. 2005]
Review Understanding how Listeria monocytogenes targets and crosses host barriers.
Lecuit M. Clin Microbiol Infect. 2005 Jun; 11(6):430-6.
Modeling human listeriosis in natural and genetically engineered animals. [Nat Protoc. 2009]
Modeling human listeriosis in natural and genetically engineered animals.
Disson O, Nikitas G, Grayo S, Dussurget O, Cossart P, Lecuit M. Nat Protoc. 2009; 4(6):799-810.
Review Listeria monocytogenes internalin and E-cadherin: from structure to pathogenesis. [Cell Microbiol. 2009]
Review Listeria monocytogenes internalin and E-cadherin: from structure to pathogenesis.
Bonazzi M, Lecuit M, Cossart P. Cell Microbiol. 2009 May; 11(5):693-702. Epub 2009 Feb 2.

See reviews... See all...

Cited by 26 PubMed Central articles

The pore-forming toxin listeriolysin O mediates a novel entry pathway of L. monocytogenes into human hepatocytes. [PLoS Pathog. 2011]
The pore-forming toxin listeriolysin O mediates a novel entry pathway of L. monocytogenes into human hepatocytes.
Vadia S, Arnett E, Haghighat AC, Wilson-Kubalek EM, Tweten RK, Seveau S. PLoS Pathog. 2011 Nov; 7(11):e1002356. Epub 2011 Nov 3.
Review Impenetrable barriers or entry portals? The role of cell-cell adhesion during infection. [J Cell Biol. 2011]
Review Impenetrable barriers or entry portals? The role of cell-cell adhesion during infection.
Bonazzi M, Cossart P. J Cell Biol. 2011 Oct 31; 195(3):349-58.
Transcytosis of Listeria monocytogenes across the intestinal barrier upon specific targeting of goblet cell accessible E-cadherin. [J Exp Med. 2011]
Transcytosis of Listeria monocytogenes across the intestinal barrier upon specific targeting of goblet cell accessible E-cadherin.
Nikitas G, Deschamps C, Disson O, Niault T, Cossart P, Lecuit M. J Exp Med. 2011 Oct 24; 208(11):2263-77. Epub 2011 Oct 3.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
Gene (GeneRIF)
Gene records that have the current articles as Reference into Function citations (GeneRIFs). NLM staff reviewing the literature while indexing MEDLINE add GeneRIFs manually.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
Nucleotide
Primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Protein Clusters
Clusters of related proteins from the Protein Clusters database that cite the current articles. Sources of references in Protein Clusters include the associated Gene and Conserved Domain records as well as NCBI added citations.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
Protein
Protein translation features of primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Conjugated action of two species-specific invasion proteins for fetoplacental li...
Conjugated action of two species-specific invasion proteins for fetoplacental listeriosis.
Nature. 2008 Oct 23 ;455(7216):1114-8. Epub 2008 Sep 17 .

PubMed
Lessons learned from studies of the natural history of diabetic nephropathy in y...
Lessons learned from studies of the natural history of diabetic nephropathy in young type 1 diabetic patients.
Pediatr Endocrinol Rev. 2008 Aug ;5 Suppl 4:958-63.

PubMed
Pathogenesis of canalicular lacerations.
Pathogenesis of canalicular lacerations.
Ophthal Plast Reconstr Surg. 2008 Sep-Oct ;24(5):394-8.

PubMed
Incidence of bacterial enteropathogens among hospitalized diarrhea patients from...
Incidence of bacterial enteropathogens among hospitalized diarrhea patients from Orissa, India.
Jpn J Infect Dis. 2008 Sep ;61(5):350-5.

PubMed
Suppression of influenza A virus nuclear antigen production and neuraminidase ac...
Suppression of influenza A virus nuclear antigen production and neuraminidase activity by a nutrient mixture containing ascorbic acid, green tea extract and amino acids.
Biofactors. 2007 ;31(1):1-15.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: