Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Neurobiol Aging. 2010 Jul;31(7):1250-3. doi: 10.1016/j.neurobiolaging.2008.08.007. Epub 2008 Sep 21.

Cardiovascular risk and memory in non-demented elderly women.

Author information

  • 1Alzheimer Disease Research Center, Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA.

Abstract

OBJECTIVE:

To determine whether cardiovascular (CV) risk is associated with subtle memory deficits in non-demented, healthy older women with a family history of Alzheimer disease (AD).

METHODS:

Baseline data of 375 participants from a randomized, double-blind placebo-controlled primary prevention trial to test the efficacy of hormone replacement therapy in delaying AD and cognitive decline were analyzed. All subjects were women over 65 with a family history of AD who had normal cognition and no active heart disease at baseline. A baseline memory composite score was calculated, consisting of immediate and delayed recall of verbal and nonverbal material. Multiple linear regression was performed to examine the association of relative CV risk with memory functioning; age, ethnicity and education level were included as covariates.

RESULTS:

Mean baseline memory composite score was significantly higher in those with low relative CHD risk than those with high relative CHD risk.

CONCLUSION:

These findings suggest that subtle elevation of CHD risk may negatively affect memory functioning even in otherwise healthy, non-demented older women without a history of heart disease.

Copyright 2008 Elsevier Inc. All rights reserved.

PMID:
18805604
[PubMed - indexed for MEDLINE]
PMCID:
PMC2900768
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk