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Cell. 2008 Sep 19;134(6):912-4. doi: 10.1016/j.cell.2008.09.007.

Putting a notch in our understanding of nuclear migration.

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  • 1Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.


The nuclei of progenitor cells in developing neural epithelia change their position during the cell cycle through a process called interkinetic nuclear migration. Del Bene et al. (2008) report that defects in the machinery controlling this process lead to altered exposure to Notch signals and systemic effects on neurogenesis in the retina.

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