Dev Cell. 2008 Sep;15(3):335-6.

FGF signaling preserves the integrity of endothelial adherens junctions.

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Department of Pharmacology and Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA.

Abstract

Fibroblast growth factor (FGF)-activated signaling regulates an array of cellular processes ranging from embryonic development to tissue repair. A recent paper by Murakami et al. identifies a potentially important role for FGF signaling in maintenance of endothelial barrier homeostasis through the regulation of adherens junctions.

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The FGF system has a key role in regulating vascular integrity. [J Clin Invest. 2008]
The FGF system has a key role in regulating vascular integrity.
Murakami M, Nguyen LT, Zhuang ZW, Moodie KL, Carmeliet P, Stan RV, Simons M. J Clin Invest. 2008 Oct; 118(10):3355-66.
Review Organization and signaling of endothelial cell-to-cell junctions in various regions of the blood and lymphatic vascular trees. [Cell Tissue Res. 2009]
Review Organization and signaling of endothelial cell-to-cell junctions in various regions of the blood and lymphatic vascular trees.
Dejana E, Orsenigo F, Molendini C, Baluk P, McDonald DM. Cell Tissue Res. 2009 Jan; 335(1):17-25. Epub 2008 Oct 15.
Induction of apoptosis in cultured endothelial cells by a cadherin antagonist peptide: involvement of fibroblast growth factor receptor-mediated signalling. [Exp Cell Res. 2004]
Induction of apoptosis in cultured endothelial cells by a cadherin antagonist peptide: involvement of fibroblast growth factor receptor-mediated signalling.
Erez N, Zamir E, Gour BJ, Blaschuk OW, Geiger B. Exp Cell Res. 2004 Apr 1; 294(2):366-78.
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Fortin D, Rom E, Sun H, Yayon A, Bansal R. J Neurosci. 2005 Aug 10; 25(32):7470-9.
Review Deciphering the functional role of endothelial junctions by using in vivo models. [EMBO Rep. 2008]
Review Deciphering the functional role of endothelial junctions by using in vivo models.
Nyqvist D, Giampietro C, Dejana E. EMBO Rep. 2008 Aug; 9(8):742-7. Epub 2008 Jul 4.

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FGF signaling preserves the integrity of endothelial adherens junctions.

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