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Dev Cell. 2008 Sep;15(3):333-4. doi: 10.1016/j.devcel.2008.08.010.

WASp identity theft by a bacterial effector.

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  • 1Rosenstiel Basic Medical Sciences Research Center, Department of Biology, Brandeis University, 415 South Street, Waltham, MA 02454, USA.


EspF(U), a protein secreted by pathogenic enterohaemorrhagic E. coli (EHEC), activates N-WASp/WASp to induce actin pedestal formation in host cells. Two recent papers in Nature show that EspF(U) exploits a WASp activation strategy so extreme that it may effectively sequester WASp, blinding it to both autoinhibition and cellular regulation.

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