Chem Biol. 2008 Sep 22;15(9):879-80.

Friend or foe? Turning a host defense protein into a pathogen's accomplice.

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Department of Pathology and Microbiology and Immunology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305-5324, USA.

Abstract

Cystatins are cysteine protease inhibitors that are at the front-line of defense against pathogens that secrete proteases as virulence factors. In this issue, Vincents et al. (2008) reveal how the bacterial protease IdeS from Streptococcus pyogenes hijacks normal cystatin C function to convert it into a cofactor that enhances proteolytic destruction of host-defense antibodies.

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Chem Biol. 2008 Sep 22;15(9):960-8.

PMID:: 18804024; [PubMed - indexed for MEDLINE]

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The human protease inhibitor cystatin C is an activating cofactor for the streptococcal cysteine protease IdeS. [Chem Biol. 2008]
The human protease inhibitor cystatin C is an activating cofactor for the streptococcal cysteine protease IdeS.
Vincents B, Vindebro R, Abrahamson M, von Pawel-Rammingen U. Chem Biol. 2008 Sep 22; 15(9):960-8.
Down-regulation of human extracellular cysteine protease inhibitors by the secreted staphylococcal cysteine proteases, staphopain A and B. [Biol Chem. 2007]
Down-regulation of human extracellular cysteine protease inhibitors by the secreted staphylococcal cysteine proteases, staphopain A and B.
Vincents B, Onnerfjord P, Gruca M, Potempa J, Abrahamson M. Biol Chem. 2007 Apr; 388(4):437-46.
Review IdeS and SpeB: immunoglobulin-degrading cysteine proteinases of Streptococcus pyogenes. [Curr Opin Microbiol. 2003]
Review IdeS and SpeB: immunoglobulin-degrading cysteine proteinases of Streptococcus pyogenes.
von Pawel-Rammingen U, Björck L. Curr Opin Microbiol. 2003 Feb; 6(1):50-5.
IdeS, a novel streptococcal cysteine proteinase with unique specificity for immunoglobulin G. [EMBO J. 2002]
IdeS, a novel streptococcal cysteine proteinase with unique specificity for immunoglobulin G.
von Pawel-Rammingen U, Johansson BP, Björck L. EMBO J. 2002 Apr 2; 21(7):1607-15.
Review Cystatins: biochemical and structural properties, and medical relevance. [Front Biosci. 2008]
Review Cystatins: biochemical and structural properties, and medical relevance.
Turk V, Stoka V, Turk D. Front Biosci. 2008 May 1; 13:5406-20. Epub 2008 May 1.

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