Nat Rev Neurosci. 2008 Oct;9(10):768-78.

Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses.

Source

Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Diseases, Department of Neurology, Massachusetts General Hospital, 114 16th Street, Charlestown, Massachusetts 02129, USA. bertram@helix.mgh.harvard.edu

Abstract

The genetic underpinnings of Alzheimer's disease (AD) remain largely elusive despite early successes in identifying three genes that cause early-onset familial AD (those that encode amyloid precursor protein (APP) and the presenilins (PSEN1 and PSEN2)), and one genetic risk factor for late-onset AD (the gene that encodes apolipoprotein E (APOE)). A large number of studies that aimed to help uncover the remaining disease-related loci have been published in recent decades, collectively proposing or refuting the involvement of over 500 different gene candidates. Systematic meta-analyses of these studies currently highlight more than 20 loci that have modest but significant effects on AD risk. This Review discusses the putative pathogenetic roles and common biochemical pathways of some of the most genetically and biologically compelling of these potential AD risk factors.

PMID:: 18802446; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Supplemental Content

Related citations

Review [Genes in Alzheimer's disease]. [Rev Neurol. 2006]
Review [Genes in Alzheimer's disease].
Hoenicka J. Rev Neurol. 2006 Mar 1-15; 42(5):302-5.
Review [Genetics of late-onset Alzheimer's disease: vascular risk and beta-amyloid metabolism]. [Recenti Prog Med. 2002]
Review [Genetics of late-onset Alzheimer's disease: vascular risk and beta-amyloid metabolism].
Panza F, Solfrizzi V, D'Introno A, Capurso C, Colacicco AM, Torres F, Altomare E, Capurso A. Recenti Prog Med. 2002 Sep; 93(9):489-97.
Review Alzheimer's disease: epidemiology, genetics, and beyond. [Neurosci Bull. 2008]
Review Alzheimer's disease: epidemiology, genetics, and beyond.
Wang XP, Ding HL. Neurosci Bull. 2008 Apr; 24(2):105-9.
Review New frontiers in Alzheimer's disease genetics. [Neuron. 2001]
Review New frontiers in Alzheimer's disease genetics.
Tanzi RE, Bertram L. Neuron. 2001 Oct 25; 32(2):181-4.
Review The current status of Alzheimer's disease genetics: what do we tell the patients? [Pharmacol Res. 2004]
Review The current status of Alzheimer's disease genetics: what do we tell the patients?
Bertram L, Tanzi RE. Pharmacol Res. 2004 Oct; 50(4):385-96.

See reviews... See all...

Cited by 56 PubMed Central articles

Molecular insights into the pathogenesis of Alzheimer's disease and its relationship to normal aging. [PLoS One. 2011]
Molecular insights into the pathogenesis of Alzheimer's disease and its relationship to normal aging.
Podtelezhnikov AA, Tanis KQ, Nebozhyn M, Ray WJ, Stone DJ, Loboda AP. PLoS One. 2011; 6(12):e29610. Epub 2011 Dec 28.
BioNØT: a searchable database of biomedical negated sentences. [BMC Bioinformatics. 2011]
BioNØT: a searchable database of biomedical negated sentences.
Agarwal S, Yu H, Kohane I. BMC Bioinformatics. 2011 Oct 27; 12:420. Epub 2011 Oct 27.
Pharmacogenetic analysis of the effects of polymorphisms in APOE, IDE and IL1B on a ketone body based therapeutic on cognition in mild to moderate Alzheimer's disease; a randomized, double-blind, placebo-controlled study. [BMC Med Genet. 2011]
Pharmacogenetic analysis of the effects of polymorphisms in APOE, IDE and IL1B on a ketone body based therapeutic on cognition in mild to moderate Alzheimer's disease; a randomized, double-blind, placebo-controlled study.
Henderson ST, Poirier J. BMC Med Genet. 2011 Oct 12; 12:137. Epub 2011 Oct 12.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Thirty years of Alzheimer's disease genetics: the implications of systematic met...
Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses.
Nat Rev Neurosci. 2008 Oct ;9(10):768-78.

PubMed
Stretching to prevent or reduce muscle soreness after exercise.
Stretching to prevent or reduce muscle soreness after exercise.
Cochrane Database Syst Rev. 2007 Oct 17 ;(4):CD004577.

PubMed
Cause-specific mortality in long-term survivors of retinoblastoma.
Cause-specific mortality in long-term survivors of retinoblastoma.
J Natl Cancer Inst. 2009 Apr 15 ;101(8):581-91. Epub 2009 Apr 7 .

PubMed
CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment ...
CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice.
Nucleic Acids Res. 1994 Nov 11 ;22(22):4673-80.

PubMed
Altered porphyrin metabolism as a biomarker of mercury exposure and toxicity.
Altered porphyrin metabolism as a biomarker of mercury exposure and toxicity.
Can J Physiol Pharmacol. 1996 Feb ;74(2):210-5.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses.

Source

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Supplemental Content

Related citations

Cited by 56 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information