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Chem Immunol Allergy. 2008;94:1-7. doi: 10.1159/000154844.

Th17 and treg cells innovate the TH1/TH2 concept and allergy research.

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  • 1Allergy and Clinical Immunology, Imperial College London, London, UK.


Allergic reactions are caused by harmless allergens, which are recognized by the specific immune system. Allergen-specific T cells are assumed to play a key role in the sensitization phase and in immunological memory. Current immunological concepts suggest that asymptomatic T-cell memory cells also exist, tagging the allergen as harmless and preventing an inappropriate response and thus allergic symptoms. Proinflammatory T cells mediate allergic inflammation by exceeding the induction of IgE and competing with other T-cell subsets. Therefore, molecular mechanisms leading to pro- or anti-inflammatory T-cell memory cells appear as the key mechanism in allergy.

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