Format

Send to:

Choose Destination
See comment in PubMed Commons below
Curr Opin Neurobiol. 2008 Jun;18(3):346-53. doi: 10.1016/j.conb.2008.08.010.

Ome sweet ome: what can the genome tell us about the connectome?

Author information

  • 1Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, Cambridge, MA 02138, USA. jeff@mcb.harvard.edu

Abstract

Some neuroscientists argue that detailed maps of synaptic connectivity--wiring diagrams--will be needed if we are to understand how the brain underlies behavior and how brain malfunctions underlie behavioral disorders. Such large-scale circuit reconstruction, which has been called connectomics, may soon be possible, owing to numerous advances in technologies for image acquisition and processing. Yet, the community is divided on the feasibility and value of the enterprise. Remarkably similar objections were voiced when the Human Genome Project, now widely viewed as a success, was first proposed. We revisit that controversy to ask if it holds any lessons for proposals to map the connectome.

PMID:
18801435
[PubMed - indexed for MEDLINE]
PMCID:
PMC2735215
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk