Comb Chem High Throughput Screen. 2008 Sep;11(8):587-601.

Expanding the chemical space in practice: diversity-oriented synthesis.

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Département de Pharmacochimie Moléculaire, Université de Grenoble/CNRS UMR 5063, CNRS ICMG FR 2607 Bâtiment E, Bâtiment André Rassat, 470 rue de la Chimie, Grenoble Cedex 9, France.

Abstract

Diversity-Oriented Synthesis (DOS) aims to broaden the frontier of accessible collections of complex and diverse small molecules. This review endeavours to dissect the DOS concept through three elements of diversity: building block, stereochemistry, and skeleton. Recent examples in the literature that emphasize the efficient combinations of these elements to generate diversity are reported.

PMID:: 18795878; [PubMed - indexed for MEDLINE]

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Expanding the chemical space in practice: diversity-oriented synthesis.

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