Pathol Res Pract. 1981 Oct;172(4):372-83.

Effect of phenobarbital on hepatic injury induced by chronic carbon tetrachloride treatment.

Source

Department of Pharmacology, University of Oulu, Finland.

Abstract

Rats were given 1 ml CCl4 per kg body weight subcutaneously 2 times a week, for 16 weeks. The effects of simultaneous phenobarbital (PB) treatment (0.05% in drinking water) on the hepatotoxicity of CCl4 was studied during 16 weeks of treatment. The retardation of growth, the increase in liver weight and mortality were greater in animals receiving both PB and CCl4 than those given CCl4 alone. Cirrhosis was apparent only in animals treated by PB + CCl4. The potentiating effect of PB on CCl4 hepatotoxicity was also seen in hexobarbital sleeping time, the rate of hexobarbital metabolism, and the cytochrome P-450 content in liver microsomes. The inducing effect of PB alone decreased with time both in vivo and in vitro, which suggests an adaptation or some kind of exhaustion of liver to the effects of PB.

PMID:: 18792759; [PubMed - indexed for MEDLINE]

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Medical

Liver Diseases - MedlinePlus Health Information

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Pivotal role of hepatocellular regeneration in the ultimate hepatotoxicity of CCl4 in chlordecone-, mirex-, or phenobarbital-pretreated rats. [Toxicol Pathol. 1992]
Pivotal role of hepatocellular regeneration in the ultimate hepatotoxicity of CCl4 in chlordecone-, mirex-, or phenobarbital-pretreated rats.
Kodavanti PR, Kodavanti UP, Faroon OM, Mehendale HM. Toxicol Pathol. 1992; 20(4):556-69.
Destruction of hepatic mixed-function oxygenase parameters by CCl4 in rats following acute treatment with chlordecone, Mirex, and phenobarbital. [Life Sci. 1983]
Destruction of hepatic mixed-function oxygenase parameters by CCl4 in rats following acute treatment with chlordecone, Mirex, and phenobarbital.
Klingensmith JS, Mehendale HM. Life Sci. 1983 Dec 5; 33(23):2339-48.
Liver damaging effect of suramin in normal and carbon-tetrachloride treated rats. [Toxicol Pathol. 1991]
Liver damaging effect of suramin in normal and carbon-tetrachloride treated rats.
Szende B, Lapis K, Jeney A, Simon K, Ordög A, Moldvay J. Toxicol Pathol. 1991; 19(3):266-72.
Review Potentiation of halomethane hepatotoxicity: chlordecone and carbon tetrachloride. [Fundam Appl Toxicol. 1984]
Review Potentiation of halomethane hepatotoxicity: chlordecone and carbon tetrachloride.
Mehendale HM. Fundam Appl Toxicol. 1984 Jun; 4(3 Pt 1):295-308.
Review [The effect of D-penicillamine on experimental liver cirrhosis induced by CCl4]. [Morphol Igazsagugyi Orv Sz. 1990]
Review [The effect of D-penicillamine on experimental liver cirrhosis induced by CCl4].
Schaff Z, Lapis K, Szende B, Jeney A, Gonzales Cabello R, Gergely P, Simon K, Divald A, Timár F, Major J. Morphol Igazsagugyi Orv Sz. 1990 Jul; 30(3):161-9.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound
PubChem chemical compound records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records. Multiple substance records may contribute to the PubChem compound record.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance
PubChem chemical substance records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.

Recent activity

Clear Turn Off Turn On

Effect of phenobarbital on hepatic injury induced by chronic carbon tetrachlorid...
Effect of phenobarbital on hepatic injury induced by chronic carbon tetrachloride treatment.
Pathol Res Pract. 1981 Oct ;172(4):372-83.

PubMed
Aspiration cytology and immunocytochemistry of sacral chordoma with liver metast...
Aspiration cytology and immunocytochemistry of sacral chordoma with liver metastases: a case report.
Diagn Cytopathol. 1991 ;7(3):277-81.

PubMed
Chronic lymphocytic leukaemia: an immunobiology approach.
Chronic lymphocytic leukaemia: an immunobiology approach.
Srp Arh Celok Lek. 2008 May-Jun ;136(5-6):319-23.

PubMed
[Medical journals and open access].
[Medical journals and open access].
Lijec Vjesn. 2008 May-Jun ;130(5-6):151-6.

PubMed
Alopecia areata in children.
Alopecia areata in children.
Cutis. 2008 Aug ;82(2):104-10.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: