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Acad Radiol. 2008 Oct;15(10):1246-54. doi: 10.1016/j.acra.2008.03.019.

Metabolic and vascular features of dynamic contrast-enhanced breast magnetic resonance imaging and (15)O-water positron emission tomography blood flow in breast cancer.

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  • 1Department of Radiology, University of Washington, Seattle Cancer Care Alliance, 825 Eastlake Avenue East, G3-200, Seattle, WA 98109-1023, USA. preby@u.washington.edu

Abstract

RATIONALE AND OBJECTIVES:

We sought to (1) describe associations between measures of tumor perfusion by dynamic contrast-enhanced breast magnetic resonance imaging (DCE-MRI), blood flow by (15)O-water positron emission tomography (PET) and metabolism by (18)F-fluorodeoxyglucose ((18)F)-FDG PET and (2) improve our understanding of tumor enhancement on MRI through independent measures of tumor metabolism and blood flow.

MATERIALS AND METHODS:

We performed a retrospective analysis of the existing PET and MRI databases from the Departments of Nuclear Medicine and Radiology. We identified patients with locally advanced breast cancer who underwent (15)O-water/(18)F-FDG PET within 1 month of clinical DCE-MRI between February 2004 and August 2006. The (15)O-water PET blood flow and (18)F-FDG metabolic rate and tissue transport constant (K(1)) in the primary malignancy were calculated. DCE-MRI peak percent enhancement and peak signal enhancement ratio (SER) were measured for each tumor. Correlations and regression analysis of these variables were performed.

RESULTS:

Fifteen patients with complete PET and DCE-MRI data were included in the analysis cohort. Peak SER correlated significantly with blood flow (r = 0.73, P = .002) and K(1) (r = 0.76, P = .001). However, peak SER did not correlate significantly with FDG metabolic rate (r = 0.44, P = .101). There were no significant correlations between peak percent enhancement and any of the PET parameters.

CONCLUSIONS:

Our findings suggest that tumor perfusion, represented by (15)O-water PET blood flow, is an important factor in the MRI enhancement of locally advanced breast cancer. A lack of correlation of FDG metabolic rate with blood flow and DCE-MRI kinetics suggests that (18)F-FDG PET provides complementary metabolic information independent of vascular factors.

PMID:
18790395
[PubMed - indexed for MEDLINE]
PMCID:
PMC2586645
Free PMC Article
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