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Pediatr Dermatol. 2008 Jul-Aug;25(4):487-8. doi: 10.1111/j.1525-1470.2008.00721.x.

Eruptive juvenile xanthogranuloma associated with relapsing acute lymphoblastic leukemia.

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  • 1Department of Dermatology, Hospital Vall d'Hebron, Universitat Autónoma de Barcelona, Barcelona, Spain. 33952gae@comb.es


Juvenile xanthogranuloma is a benign, self-healing disorder with characteristic lesions mainly involving the skin. Although most patients with juvenile xanthogranuloma have only cutaneous symptoms, recent articles have documented extracutaneous manifestations: systemic involvement of many organs has been reported and there is a known association between juvenile xanthogranuloma and childhood leukemia, most commonly juvenile chronic myelogenous leukemia. This case provides further corroboration, that in rare instances, juvenile xanthogranuloma may be associated with hematologic malignancies.

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