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Nat Rev Immunol. 2008 Oct;8(10):753-63. doi: 10.1038/nri2400.

The alliance of sphingosine-1-phosphate and its receptors in immunity.

Author information

  • 1Laboratory of Immune Cell Signaling, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland 20892, USA. juan.rivera@nih.gov

Abstract

Sphingosine-1-phosphate (S1P) is a biologically active metabolite of plasma-membrane sphingolipids that is essential for immune-cell trafficking. Its concentration is increased in many inflammatory conditions, such as asthma and autoimmunity. Much of the immune function of S1P results from the engagement of a family of G-protein-coupled receptors (S1PR1-S1PR5). Recent findings on the role of S1P in immunosurveillance, the discovery of regulatory mechanisms in S1P-mediated immune-cell trafficking and new advances in understanding the mechanism by which S1P affects immune-cell function indicate that the alliance between S1P and its receptors has a fundamental role in immunity.

PMID:
18787560
[PubMed - indexed for MEDLINE]
PMCID:
PMC2600775
Free PMC Article

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