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Science. 2008 Sep 12;321(5895):1462. doi: 10.1126/science.1162525.

A mutation in hairless dogs implicates FOXI3 in ectodermal development.

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  • 1University of Berne, 3001 Berne, Switzerland.

Abstract

Mexican and Peruvian hairless dogs and Chinese crested dogs are characterized by missing hair and teeth, a phenotype termed canine ectodermal dysplasia (CED). CED is inherited as a monogenic autosomal semidominant trait. With genomewide association analysis we mapped the CED mutation to a 102-kilo-base pair interval on chromosome 17. The associated interval contains a previously uncharacterized member of the forkhead box transcription factor family (FOXI3), which is specifically expressed in developing hair and teeth. Mutation analysis revealed a frameshift mutation within the FOXI3 coding sequence in hairless dogs. Thus, we have identified FOXI3 as a regulator of ectodermal development.

PMID:
18787161
[PubMed - indexed for MEDLINE]
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