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Curr Biol. 2008 Sep 9;18(17):R759-R768. doi: 10.1016/j.cub.2008.07.001.

Temporal organization of the cell cycle.

Author information

  • 1Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA. tyson@vt.edu

Abstract

The coordination of growth, DNA replication and division in proliferating cells can be adequately explained by a 'clock + checkpoint' model. The clock is an underlying cyclical sequence of states; the checkpoints ensure that the cycle proceeds without mistakes. From the molecular complexities of the control system in modern eukaryotes, we isolate a simple network of positive and negative feedbacks that embodies a 'clock + checkpoints'. The model accounts for the fundamental physiological properties of mitotic cell divisions, evokes a new view of the meiotic program, and suggests how the control system may have evolved in the first place.

PMID:
18786381
[PubMed - indexed for MEDLINE]
PMCID:
PMC2856080
Free PMC Article

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