J Proteome Res. 2008 Oct;7(10):4373-83. Epub 2008 Sep 12.

Differential mass spectrometry of rat plasma reveals proteins that are responsive to 17beta-estradiol and a selective estrogen receptor modulator PPT.

Zhao X, Deyanova EG, Lubbers LS, Zafian P, Li JJ, Liaw A, Song Q, Du Y, Settlage RE, Hickey GJ, Yates NA, Hendrickson RC.

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Department of Proteomics, Merck Research Laboratories, Rahway, New Jersey 07065, USA.

Abstract

Estrogens are a class of steroid hormones that interact with two related but distinct nuclear receptors, estrogen receptor (ER) alpha and beta. To identify potential ER biomarkers, we profiled the rat plasma glycoproteome after treatment with vehicle or 17beta-estradiol (E2) or an ERalpha-selective agonist PPT by differential mass spectrometry. Our comparative proteomic experiment identifies novel E2- and PPT-responsive proteins, such as serine protease inhibitor family members.

PMID:: 18785765; [PubMed - indexed for MEDLINE]

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Chemical compound information

1,3,5-tris(4-hydroxyphenyl)-4-propyl-1H-pyrazole

MW: 386.44 g/mol

MF: C₂₄H₂₂N₂O₃

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Differential mass spectrometry of rat plasma reveals proteins that are responsive to 17beta-estradiol and a selective estrogen receptor modulator PPT.

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