Rheumatology (Oxford). 2008 Oct;47 Suppl 5:v65-7.

Pulmonary function tests.

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Department of Internal Medicine, Grosshadern clinic, Ludwig Maximilians University of Munich, Munich, Germany. jbehr@med1.med.uni-muenchen.de

Abstract

Systemic sclerosis-associated interstitial lung disease (SSc-ILD) is the leading cause of morbidity and mortality in SSc patients. In autopsy studies, up to 70% of the SSc patients show histological evidence of lung involvement. In surgical lung biopsies from SSc-ILD patients, a pattern of non-specific interstitial pneumonia is present in a majority, while usual interstitial pneumonia is found in a more variable proportion of patients. Up to 90% of the SSc patients have lung function abnormalities, especially with respect to gas transfer. Pulmonary function testing, therefore, is a major tool of investigation of lung involvement in SSc.

PMID:: 18784151; [PubMed - indexed for MEDLINE]

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