Radiother Oncol. 2009 Jan;90(1):1-13. Epub 2008 Sep 8.

Accelerated partial breast irradiation as part of breast conserving therapy of early breast carcinoma: a systematic review.

Offersen BV, Overgaard M, Kroman N, Overgaard J.

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Department of Oncology, Aarhus University Hospital, Aarhus C, Denmark. bvo@oncology.dk

Erratum in

Radiother Oncol. 2011 May;99(2):254.
Radiother Oncol. 2011 Feb;98(2):254.

Abstract

New strategies for adjuvant radiotherapy of early breast cancer are being investigated in several phase III randomised trials at the present time. Accelerated partial breast irradiation (APBI) is a way to offer an early breast cancer patient, who has had breast conservative surgery, an adjuvant radiotherapy of short duration aimed at the tumour bed with a certain margin. The rationale of this strategy is that most local recurrences appear close to the tumorectomy cavity and a wish to spare the patient late radiation morbidity. This review discusses the background for APBI, the different techniques, and we highlight possible pitfalls using these techniques. A systematic overview of all phase I and II studies is provided. Patient selection for this therapy is pivotal and based on evidence from previous studies on patient/tumour characteristics and pattern of local recurrences we propose inclusion criteria for patients in APBI protocols.

Comment in

Radiother Oncol. 2010 Mar;94(3):388-9; author reply 390.

PMID:: 18783840; [PubMed - indexed for MEDLINE]

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