Br J Cancer. 2008 Nov 4;99(9):1369-74. Epub 2008 Sep 9.

Mammographic density, lobular involution, and risk of breast cancer.

Source

Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, Canada.

Abstract

In this review, we propose that age-related changes in mammographic density and breast tissue involution are closely related phenomena, and consider their potential relevance to the aetiology of breast cancer. We propose that the reduction in mammographic density that occurs with increasing age, parity and menopause reflects the involution of breast tissue. We further propose that age-related changes in both mammographic density and breast tissue composition are observable and measurable phenomena that resemble Pike's theoretical construct of 'breast tissue ageing'. Extensive mammographic density and delayed breast involution are both associated with an increased risk of breast cancer and are consistent with the hypothesis of the Pike model that cumulative exposure of breast tissue to hormones and growth factors that stimulate cell division, as well as the accumulation of genetic damage in breast cells, are major determinants of breast cancer incidence.

PMID:: 18781174; [PubMed - indexed for MEDLINE]
PMCID:: PMC2579686

Free PMC Article

Images from this publication.See all images (3) Free text

Publication Types, MeSH Terms

Publication Types

Review

MeSH Terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Medical

Supplemental Content

Save items

Related citations in PubMed

Review Mammographic density: a hormonally responsive risk factor for breast cancer. [J Br Menopause Soc. 2006]
Review Mammographic density: a hormonally responsive risk factor for breast cancer.
Boyd NF, Martin LJ, Yaffe MJ, Minkin S. J Br Menopause Soc. 2006 Dec; 12(4):186-93.
Review Mammographic density. Potential mechanisms of breast cancer risk associated with mammographic density: hypotheses based on epidemiological evidence. [Breast Cancer Res. 2008]
Review Mammographic density. Potential mechanisms of breast cancer risk associated with mammographic density: hypotheses based on epidemiological evidence.
Martin LJ, Boyd NF. Breast Cancer Res. 2008; 10(1):201. Epub 2008 Jan 9.
Review Mammographic density as a marker of susceptibility to breast cancer: a hypothesis. [IARC Sci Publ. 2001]
Review Mammographic density as a marker of susceptibility to breast cancer: a hypothesis.
Boyd NF, Lockwood GA, Martin LJ, Byng JW, Yaffe MJ, Tritchler DL. IARC Sci Publ. 2001; 154:163-9.
Independent association of lobular involution and mammographic breast density with breast cancer risk. [J Natl Cancer Inst. 2010]
Independent association of lobular involution and mammographic breast density with breast cancer risk.
Ghosh K, Vachon CM, Pankratz VS, Vierkant RA, Anderson SS, Brandt KR, Visscher DW, Reynolds C, Frost MH, Hartmann LC. J Natl Cancer Inst. 2010 Nov 17; 102(22):1716-23. Epub 2010 Oct 29.
Association between mammographic density and age-related lobular involution of the breast. [J Clin Oncol. 2010]
Association between mammographic density and age-related lobular involution of the breast.
Ghosh K, Hartmann LC, Reynolds C, Visscher DW, Brandt KR, Vierkant RA, Scott CG, Radisky DC, Sellers TA, Pankratz VS, et al. J Clin Oncol. 2010 May 1; 28(13):2207-12. Epub 2010 Mar 29.

See reviews... See all...

Cited by 10 PubMed Central articles

Obstetric history and mammographic density: a population-based cross-sectional study in Spain (DDM-Spain). [Breast Cancer Res Treat. 2012]
Obstetric history and mammographic density: a population-based cross-sectional study in Spain (DDM-Spain).
Lope V, Pérez-Gómez B, Sánchez-Contador C, Santamariña MC, Moreo P, Vidal C, Laso MS, Ederra M, Pedraz-Pingarrón C, González-Román I, et al. Breast Cancer Res Treat. 2012 Apr; 132(3):1137-46. Epub 2012 Jan 4.
Localized fibroglandular tissue as a predictor of future tumor location within the breast. [Cancer Epidemiol Biomarkers Pr...]
Localized fibroglandular tissue as a predictor of future tumor location within the breast.
Pinto Pereira SM, McCormack VA, Hipwell JH, Record C, Wilkinson LS, Moss SM, Hawkes DJ, dos-Santos-Silva I. Cancer Epidemiol Biomarkers Prev. 2011 Aug; 20(8):1718-25. Epub 2011 Jun 21.
Aligned collagen is a prognostic signature for survival in human breast carcinoma. [Am J Pathol. 2011]
Aligned collagen is a prognostic signature for survival in human breast carcinoma.
Conklin MW, Eickhoff JC, Riching KM, Pehlke CA, Eliceiri KW, Provenzano PP, Friedl A, Keely PJ. Am J Pathol. 2011 Mar; 178(3):1221-32.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Mammographic density, lobular involution, and risk of breast cancer.
Mammographic density, lobular involution, and risk of breast cancer.
Br J Cancer. 2008 Nov 4 ;99(9):1369-74. Epub 2008 Sep 9 .

PubMed
A paramutation phenomenon is involved in the genetics of maize low phytic acid1-...
A paramutation phenomenon is involved in the genetics of maize low phytic acid1-241 (lpa1-241) trait.
Heredity (Edinb). 2009 Mar ;102(3):236-45. Epub 2008 Sep 10 .

PubMed
Early onset of breast cancer in Black British women: how reliable are the findin...
Early onset of breast cancer in Black British women: how reliable are the findings?
Br J Cancer. 2008 Sep 16 ;99(6):986-7; author reply 988.

PubMed
In vivo modulation of Nogo-B attenuates neointima formation.
In vivo modulation of Nogo-B attenuates neointima formation.
Mol Ther. 2008 Nov ;16(11):1798-804. Epub 2008 Sep 9 .

PubMed
Reliability of Concentric and Eccentric Measurements of Quadriceps Performance U...
Reliability of Concentric and Eccentric Measurements of Quadriceps Performance Using the KIN-COM Dynamometer: The Effect of Testing Order for Three Different Speeds.
J Orthop Sports Phys Ther. 1992 ;15(4):175-82.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: