Format

Send to:

Choose Destination
See comment in PubMed Commons below
Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14644-9. doi: 10.1073/pnas.0803185105. Epub 2008 Sep 9.

GLD2 poly(A) polymerase is required for long-term memory.

Author information

  • 1Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA.

Abstract

The formation of long-term memory is believed to require translational control of localized mRNAs. In mammals, dendritic mRNAs are maintained in a repressed state and are activated upon repetitive stimulation. Several regulatory proteins required for translational control in early development are thought to be required for memory formation, suggesting similar molecular mechanisms. Here, using Drosophila, we identify the enzyme responsible for poly(A) elongation in the brain and demonstrate that its activity is required specifically for long-term memory. These findings provide strong evidence that cytoplasmic polyadenylation is critical for memory formation, and that GLD2 is the enzyme responsible.

PMID:
18780789
[PubMed - indexed for MEDLINE]
PMCID:
PMC2567210
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk