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Cell Host Microbe. 2008 Sep 11;4(3):196-7. doi: 10.1016/j.chom.2008.08.008.

Host-retrovirus arms race: trimming the budget.

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  • 1Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA.


In this issue of Cell Host & Microbe, OhAinle et al., 2008 report that APOBEC3H, a potent innate retroviral restriction factor in primates, lost its function twice independently during recent evolution in humans, stressing an ever present trade-off between benefit and cost of protection against pathogens.

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