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Anal Bioanal Chem. 2009 Jan;393(1):31-5. doi: 10.1007/s00216-008-2367-3. Epub 2008 Sep 7.

Lipid imaging with cluster time-of-flight secondary ion mass spectrometry.

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  • 1CNRS, Institut de Chimie des Substances Naturelles, Laboratoire de Spectrométrie de Masse, UPR 2301, Av. de la Terrasse, 91198, Gif-sur-Yvette, France.


This brief article provides an overview of the current state of the art in biological imaging mass spectrometry using cluster time-of-flight secondary ion mass spectrometry (TOF-SIMS). Recent and spectacular improvements in terms of sensitivity of TOF-SIMS imaging methods have allowed many biological applications to recently be successfully tested, such as mapping of lipid disorders in human muscles of a patient suffering from dystrophy, localization of surfactins after the swarming of bacteria on a surface, or lipid mapping over whole-body animal sections.

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