Biosci Biotechnol Biochem. 2008 Sep;72(9):2476-80. Epub 2008 Sep 7.

Extract from Acanthopanax senticosus harms (Siberian ginseng) activates NTS and SON/PVN in the rat brain.

Soya H, Deocaris CC, Yamaguchi K, Ohiwa N, Saito T, Nishijima T, Kato M, Tateoka M, Matsui T, Okamoto M, Fujikawa T.

Source

Laboratory of Exercise Biochemistry, University of Tsukuba Graduate School of Comprehensive Human Sciences, Tsukuba, Japan. hsoya@taiiku.tsukuba.ac.jp

Abstract

The extract of the stem bark of Siberian ginseng, Acanthopanax senticosus Harms (ASH), is believed to play a body-coping role in stress through a brain noradrenergic mechanism. The present study was carried out to investigate the effect of ASH on the neuronal activation patterns of c-Fos expression in the rat brain. With ASH administration, c-Fos accumulated in both the supraoptic nuclei (SON) and paraventricular nuclei (PVN), which regulate stress response. Only the caudal regions in the nucleus of the solitary tract (NTS), a locus innervating both the SON and PVN, were activated. Such a neuro-anatomical pattern associated with ASH suggests the possible involvement of these stress-related brain loci.

PMID:: 18776662; [PubMed - indexed for MEDLINE]

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