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    Nucleic Acids Res. 2008 Oct;36(18):5750-62. Epub 2008 Sep 6.

    RAG2's non-core domain contributes to the ordered regulation of V(D)J recombination.

    Curry JD, Schlissel MS.

    Source

    Division of Immunology, Department of Molecular and Cell Biology, University of California at Berkeley, 439 Life Sciences Addition, Berkeley, CA 94720-3200, USA.

    Abstract

    Variable (diversity) joining [V(D)J] recombination of immune gene loci proceeds in an ordered manner with D to J portions recombining first and then an upstream V joins that recombinant. We present evidence that the non-core domain of recombination activating gene (RAG) protein 2 is involved in the regulation of recombinatorial order. In mice lacking the non-core domain of RAG2 the ordered rearrangement is disturbed and direct V to D rearrangements are 10- to 1000-times increased in tri-partite immune gene loci. Some forms of inter-chromosomal translocations between TCRbeta and TCRdelta D gene segments are also increased in the core RAG2 animals as compared with their wild-type (WT) counterparts. In addition, the concise use of proper recombination signal sequences (RSSs) appears to be disturbed in the core RAG2 mice as compared with WT RAG2 animals.

    PMID:
    18776220
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC2566892
    Free PMC Article

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