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J Antimicrob Chemother. 2008 Nov;62(5):860-5. doi: 10.1093/jac/dkn346. Epub 2008 Sep 5.

Treatment of acute hepatitis C: the success of monotherapy with (pegylated) interferon alpha.

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  • 1Department of Internal Medicine, Medical Clinic and Polyclinic II, University of Leipzig, Leipzig, Germany.


Early control in the acute phase of hepatitis C infection is an attractive therapeutic goal in order to shorten disease duration and infectivity, to prevent chronicity and progression to advanced liver disease and to avoid eventual therapeutic non-response in the later stages of chronic hepatitis C. Over the past decade, different interferon-based treatment options have been developed, which lead to sustained virological response rates of up to 98%. The present article summarizes the successful invention of immediate and delayed strategies in acute hepatitis C monoinfection, critically discusses potential limitations and illustrates the therapeutic challenges of the near future.

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