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Curr Opin Genet Dev. 2008 Oct;18(5):441-8. doi: 10.1016/j.gde.2008.07.015. Epub 2008 Sep 5.

Transcriptional regulation of lymphocyte development.

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  • 1Department of Pathology, The University of Chicago, Chicago, IL 60637, USA.


B lymphocytes and T lymphocytes develop from hematopoietic stem cells through a series of intermediates with progressively decreased lineage differentiation potential. Differentiation is preceded by increased accessibility of the chromatin at genes that are poised for expression in the progeny of a multipotent cell. During the process of differentiation there is increased expression of lineage-associated genes and repression of lineage-inappropriate genes resulting in commitment to differentiation through a specific lineage. These transcriptional events are coordinated by networks of transcription factors and their associated chromatin remodeling factors. The B lymphocyte lineage provides a paradigm for how these events unfold to promote specification and commitment to a single developmental pathway.

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