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Eur J Med Chem. 2009 Apr;44(4):1570-8. doi: 10.1016/j.ejmech.2008.07.024. Epub 2008 Jul 26.

Design, synthesis, structure-activity relationship and antibacterial activity series of novel imidazo fused quinolone carboxamides.

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  • 1Fluoroorganic Division, Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad, Andhrapradesh 500007, India.

Abstract

A series of novel 7,8 and 1,8 imidazo fused quinolone carboxamides are synthesized and evaluated against antibacterial activity. 1,8 Imidazo fused quinolones exhibit moderate antibacterial activity. Molecular modeling studies were carried out to optimize the pharmacophore.

PMID:
18775585
[PubMed - indexed for MEDLINE]
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