Source
Nanyang Technological University, School of Chemical and Biomedical Engineering, Division of Bioengineering, 70 Nanyang Drive, N1.3-B2-13, Singapore 637457, Republic of Singapore.
Abstract
BACKGROUND:
Engineered organogenesis is one of the most challenging areas on the cutting edge of regenerative medicine. Growth factors can affect cell proliferation, migration and differentiation profoundly, and thus play a critical role in tissue regeneration. TGF-betas produce a wide range of effects in different cells and tissues. TGF-beta3 is relatively recently discovered and studied.
OBJECTIVE:
To provide a broader understanding of the current state of TGF-beta3 in engineered osteogenesis, chondrogenesis, palate development, scar-free wound healing, odontogenesis and neurogenesis.
METHODS:
This review summarizes studies that explore or apply TGF-beta3 for organogenesis with engineering methodology and a regenerative medical perspective.
RESULTS/CONCLUSION:
TGF-beta3 has proven to be a competent growth factor in engineered organogenesis in vitro. In recent years, using TGF-beta3, more and more in vivo studies have yielded significant therapeutic achievements in animal models, which bear much promise for future medical application.