Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Psychoneuroendocrinology. 2008 Nov;33(10):1322-34. doi: 10.1016/j.psyneuen.2008.07.006. Epub 2008 Sep 5.

Inflammatory markers and cognitive function in middle-aged adults: the Whitehall II study.

Author information

  • 1International Institute for Society and Health, Department of Epidemiology and Public Health, UCL Medical School, London, UK. d.gimeno@ucl.ac.uk

Abstract

OBJECTIVES:

To assess whether C-reactive protein (CRP) and interleukin-6 (IL-6) are associated with low cognitive performance and decline in middle-aged adults.

DESIGN/SETTING:

The Whitehall II study; an ongoing large-scale, prospective occupational cohort study of employees from 20 London-based white-collar Civil Service departments.

PARTICIPANTS:

Data from more than 3000 males and 1200 female employees.

MEASURES:

Inflammatory makers measured in 1991-1993 and five cognitive tests (short-term verbal memory, inductive reasoning (AH4-I), vocabulary (Mill Hill), and phonemic and semantic fluency) performed in 1997-1999 and 2002-2004. Performance in the lowest sex-specific quintile indicated low cognitive performance or decline. Covariates included sociodemographics, health behaviours and health conditions.

RESULTS:

In age-adjusted analyses both CRP and IL-6 were associated with all cognitive measures in 1997-1999, even though the association with memory was not consistent. After extensive adjustment raised CRP levels were only associated with poor cognitive performance on the AH4-I (OR=1.38; 95% CI: 1.05-1.82) and Mill Hill (OR=1.52; 95% CI: 1.14-2.03) and IL-6 on semantic fluency (OR=1.27; 95% CI: 1.14-2.03). Associations were more evident in men than in women. No clear relationship was observed for decline.

CONCLUSIONS:

Our results suggest that raised levels of inflammatory markers in midlife are moderately associated with lower cognitive status, but little with cognitive decline.

PMID:
18774232
[PubMed - indexed for MEDLINE]
PMCID:
PMC2613425
Free PMC Article

Images from this publication.See all images (1)Free text

Figure 1
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk