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    Optom Vis Sci. 2008 Sep;85(9):E795-801.

    Management of evaporative dry eye in ectrodactyly-ectodermal dysplasia-clefting syndrome.

    Ota Y, Matsumoto Y, Dogru M, Goto E, Uchino Y, Endo K, Tsubota K.

    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.

    PURPOSE: The purpose of this study is to report the features of dry eye and ocular surface disease in an unusual case of ectrodactyly-ectodermal dysplasia-clefting (EEC) syndrome. CASE REPORT: A single observational case report of a 22-year-old Japanese male with evaporative dry eye and corneal epithelial disease because of lipid layer abnormality resulting from meibomian gland agenesis was treated successfully with low dose lipid base ointment application. DISCUSSION: The clinical features of the dry eye and ocular surface disease and management issues are discussed. CONCLUSION: Low dose lipid base ointment application may be a promising treatment modality for the ocular surface disease in ectrodactyly-ectodermal dysplasia (EEC)-clefting syndrome, which seems to help in alleviating the subjective complaints and in improving the objective clinical findings.

    PMID: 18772710 [PubMed - indexed for MEDLINE]

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