Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Gerontol A Biol Sci Med Sci. 2008 Aug;63(8):809-12.

Association of longer telomeres with better health in centenarians.

Author information

  • 1New England Centenarian Study, Geriatrics Section of the Department of Medicine, Boston Medical Center, Boston University School of Medicine, 88 East Newton Street, Boston, MA 02118, USA. laterry@bu.edu

Abstract

Prior animal model studies have demonstrated an association between telomere length and longevity. Our study examines telomere length in centenarians in good health versus poor health. Using DNA from blood lymphocytes, telomere length was measured by quantitative polymerase chain reaction in 38 sex- and age-matched centenarians (ages 97-108). "Healthy" centenarians (n = 19) with physical function in the independent range and the absence of hypertension, congestive heart failure, myocardial infarction, peripheral vascular disease, dementia, cancer, stroke, chronic obstructive pulmonary disease, and diabetes were compared to centenarians with physical function limitations and > or =2 of the above conditions (n = 19). Healthy centenarians had significantly longer telomeres than did unhealthy centenarians (p =.0475). Our study demonstrated that investigations of the association between telomere length and exceptional longevity must take into account the health status of the individuals. This raises the possibility that perhaps it is not exceptional longevity but one's function and health that may be associated with telomere length.

PMID:
18772468
[PubMed - indexed for MEDLINE]
PMCID:
PMC2892727
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk