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Am J Obstet Gynecol. 2008 Sep;199(3):278.e1-5. doi: 10.1016/j.ajog.2008.06.066.

The association of intrauterine growth abnormalities in women with type 1 diabetes mellitus complicated by vasculopathy.

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  • 1Department of Obstetrics and Gynecology, Washington Hospital Center, Washington, DC, USA.



The purpose of this study was to test whether vasculopathy in type 1 diabetes mellitus (DM) is associated with fetal growth abnormalities.


Women with type 1 DM (n = 340) were enrolled in a prospective study of diabetes in pregnancy and classified according to vascular status: NV (no vasculopathy, n = 181), HBR (hypertension or background retinopathy, n = 79), PR (proliferative retinopathy only, n = 16), NEP (nephropathy only, n = 40), and PRN (proliferative retinopathy and nephropathy, n = 24). Association of vascular status with low birthweight (LBW) and small for gestational age (SGA) infants was analyzed.


The odds ratios for delivery of a LBW infant compared to women without vasculopathy after controlling for maternal age, gestational age and race were: HBR 1.0, PR 2.2, NEP 3.7, and PRN 5.5. The odds ratios for delivery of a SGA infant were: HBR 0.7, PR 10.4, NEP 1.9, and PRN 9.9.


Diabetic vasculopathy is associated with increased odds for delivery of low-birthweight or SGA infants.

[PubMed - indexed for MEDLINE]
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