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Genome Biol. 2008;9(8):231. doi: 10.1186/gb-2008-9-8-231. Epub 2008 Sep 1.

Reduced-representation methylation mapping.

Author information

  • 1Roche NimbleGen Inc, Research and Development, 500 S. Rosa Rd, Madison, WI 53719, USA. jeffrey.jeddeloh@roche.com

Abstract

The power of massively parallel sequencing has been harnessed to map cytosine methylation patterns in the mouse genome, allowing insights into the relationship of methylation with DNA sequence, histone modifications, transcriptional activity and dynamic changes in methylation status during differentiation.

PMID:
18771577
[PubMed - indexed for MEDLINE]
PMCID:
PMC2575507
Free PMC Article
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