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Trends Biochem Sci. 1991 Apr;16(4):135-40.

Is hsp70 the cellular thermometer?

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  • 1Department of Physiological Chemistry, University of Wisconsin-Madison 53706.

Abstract

Cells respond to an increase in temperature by inducing the synthesis of the heat shock proteins, which are a small set of evolutionarily conserved proteins. We review the evidence leading us to suggest that the free pool of one of these proteins, hsp70, serves as a cellular thermometer that regulates the expression of all heat shock proteins.

PMID:
1877088
[PubMed - indexed for MEDLINE]
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