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Cell Physiol Biochem. 2008;22(1-4):287-94. doi: 10.1159/000149807. Epub 2008 Jul 25.

Caveolin and proteasome in tocotrienol mediated myocardial protection.

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  • 1Cardiovascular Research Center, University of Connecticut School of Medicine, Farmington, CT 06030-1110, USA.

Abstract

The effect of different isomers of tocotrienol was tested on myocardial ischemia reperfusion injury. Although all of the tocotrienol isomers offered some degree of cardioprotection, gamma-tocotrienol was the most protective as evident from the result of myocardial apoptosis. To study the mechanism of tocotrienol mediated cardioprotection, we examined the interaction and/or translocation of different signaling components to caveolins and activity of proteasome. The results suggest that differential interaction of MAP kinases with caveolin 1/3 in conjuncture with proteasome stabilization play a unique role in tocotrienol mediated cardioprotection possibly by altering the availability of pro-survival and anti-survival proteins.

Copyright 2008 S. Karger AG, Basel.

PMID:
18769056
[PubMed - indexed for MEDLINE]
PMCID:
PMC2929803
Free PMC Article
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