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J Virol. 2008 Nov;82(22):11472-5. Epub 2008 Sep 3.

Glutamine deprivation causes enhanced plating efficiency of a herpes simplex virus type 1 ICP0-null mutant.

Bringhurst RM, Dominguez AA, Schaffer PA.

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University of Arizona, 1007 E. Lowell St., P.O. Box 210106, Tucson, AZ 85721, USA. rbring@email.arizona.edu

Abstract

Isoleucine deprivation of cellular monolayers prior to infection has been reported to result in partial complementation of a herpes simplex virus type 1 (HSV-1) ICP0 null (ICP0(-)) mutant. We now report that glutamine deprivation alone is able to enhance the plating efficiency of an ICP0(-) virus and that isoleucine deprivation has little or no effect. Because a low glutamine level is associated with stress and because stress is known to induce reactivation, low levels of glutamine may be relevant to the reactivation of HSV-1 from latency. Additionally, we demonstrate that arginine and methionine deprivation result in partial complementation of the ICP0(-) virus.

PMID:: 18768961; [PubMed - indexed for MEDLINE]
PMCID:: PMC2573270

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