Send to:

Choose Destination
See comment in PubMed Commons below
J Biol Chem. 2008 Nov 7;283(45):30964-9. doi: 10.1074/jbc.M806242200. Epub 2008 Sep 2.

Two patched protein subtypes and a conserved domain of group I proteins that regulates turnover.

Author information

  • 1Department of Biochemistry and Biophysics, University of California, San Francisco, California 94158, USA.


Patched (Ptc) is a 12-cross membrane protein that binds the secreted Hedgehog protein. Its regulation of the Hedgehog signaling pathway is critical to normal development and to a number of human diseases. This report analyzes features of sequence similarity and divergence in the Ptc protein family and identifies two subtypes distinguished by novel conserved domains. We used these results to propose a rational basis for classification. We show that one of the conserved sequence regions in the C-terminal domain of Ptch1 is responsible, at least in part, for rapid turnover. This sequence is absent in the stable Ptch2 protein.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk