Forensic Sci Int. 2008 Sep 18;180(2-3):105-9. Epub 2008 Sep 2.

Determination of salvinorin A and salvinorin B in Salvia divinorum-related products circulated in Japan.

Tsujikawa K, Kuwayama K, Miyaguchi H, Kanamori T, Iwata YT, Yoshida T, Inoue H.

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National Research Institute of Police Science, 6-3-1 Kashiwanoha, Kashiwa, Chiba 277-0882, Japan. tujikawa@nrips.go.jp

Abstract

Two major salvinorins, salvinorin A (SalA) and salvinorin B (SalB), in three Salvia divinorum dried leaf products and nine of its "concentrated extract" products circulated in Japan were determined. These ingredients were extracted twice with acetonitrile and decolored with graphite carbon powder. SalA and SalB were confirmed by liquid chromatography-tandem mass spectrometry in product ion scan mode, and quantified by high-performance liquid chromatography with UV detection (for SalA) and by mass spectrometry in single ion monitoring mode (for SalB). The SalA/SalB contents (mug/mg) were in the range of 3.2-5.0/0.10-0.17 in the dried leaf products and 4.1-38.9/0.26-2.42 in the "concentrated extract" products. These findings would be useful for analysis of S. divinorum-related products circulated in the drug market.

PMID:: 18768273; [PubMed - indexed for MEDLINE]

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