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Pediatr Diabetes. 2008 Jul 28;9(4 Pt 1):320-5. doi: 10.1111/j.1399-5448.2008.00393.x.

Low-fat vs. high-fat bedtime snacks in children and adolescents with type 1 diabetes.

Author information

  • 1Division of Pediatric Endocrinology and Diabetes, Stanford University, Stanford, CA, USA. direcnet@jaeb.org

Abstract

OBJECTIVE:

The purpose of this study was to determine whether, in a group of children with type 1 diabetes using insulin pump, a prebedtime snack with a relatively high fat content provides greater protection from nocturnal hypoglycemia than a snack containing the same amount of carbohydrate and protein but a lower fat content.

RESEARCH DESIGN AND METHODS:

Ten subjects, aged 6 to <18 yr, in a trial evaluating the Abbott Navigator glucose sensor, agreed to this ancillary study. On 12 or more separate nights, each subject was randomized by a Web site to a carbohydrate-low-fat (30 g CHO, 2.5 g protein, and 1.3 g fat; 138 kcal) snack or a carbohydrate-high-fat (30 g CHO, 2 g protein, and 20 g fat; 320 kcal) snack. Subjects used their usual evening snack algorithm to determine the size (in 15-g carbohydrate increments) and insulin dosage.

RESULTS:

Average glucose on 128 valid study nights before snack was similar in both groups. The proportion of nights with hypoglycemia (a sensor or meter glucose value <or=70 mg/dL) was similar in both groups (19% high fat vs. 20% low fat), as was the proportion of nights with hyperglycemia (a glucose >or=200 mg/dL and at least 50 mg/dL above baseline, 35% high fat vs. 30% low fat).

CONCLUSIONS:

There were no statistical differences between the high- and low-fat snacks on the frequency of hyperglycemia or hypoglycemia. This study highlights the feasibility of web-based research in patients' home environment.

PMID:
18768036
[PubMed - indexed for MEDLINE]
PMCID:
PMC2593894
Free PMC Article

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